Maria Semple's novel Where'd You Go, Bernadette, shortlisted for this year's Women's Prize for Fiction, has won the Melissa Nathan Award for comedy fiction.
The book, published by Weidenfeld & Nicolson, was selected from a shortlist of five titles, chosen from more than 90 submitted entries.
The prize, which is currently seeking a new sponsor, was first awarded in 2007 in memory of novelist Melissa Nathan.
Semple said: "As Melissa Nathan knew only too well, it's hard work making comedy look easy. I'm so grateful that Where'd You Go, Bernadette has been acknowledged for its heart and humour."
The other shortlisted titles were Charlotte Street by Danny Wallace (Ebury Press), You Had Me At Hello by Mhairi McFarlane (HarperCollins), Summer Daydreams by Carole Matthews (Sphere), Eleanor & Park by Rainbow Rowell (Orion) and The Wedding Diaries by Sam Binnie (HarperCollins).
Andrew Saffron, Nathan's husband, who organises the award, said the prize was now looking for new sponsors to take on "a new and rewarding sponsorship opportunity".