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Fiona McIntosh, publicity director of HarperFiction, has left the publisher after 12 years "to pursue new opportunities".
Liz Dawson, who has been working for HarperCollins in a freelance capacity, has been appointed acting PR director for fiction.
In a statement, a HarperCollins spokesperson said: "Fiona has played a major part in the success of HarperFiction. She has many friends here and her expertise and commitment will be sadly missed.
"We wish her the best of luck for the future."